After losing the first two starts of her 4-year-old campaign, Rachel Alexandra goes for her first win of 2010 in today’s Grade II, $200,000-added Fleur de Lis Handicap at Churchill Downs.

Rachel Alexandra ran a perfect 8-for-8 campaign last year, including Grade I victories over males at three different tracks — the Preakness at Pimlico, the Haskell Invitational at Monmouth and the Woodward at Saratoga. She also earned dominant 20-length victories over her own sex in the Kentucky Oaks and the Mother Goose.

In March, Rachel Alexandra returned from a layoff of six-plus months in the New Orleans Ladies at the Fair Grounds. She finished second by three-quarters of a length to graded winner Zardana. Off the layoff and with trainer Steve Asmussen admitting his charge wasn’t yet completely fit, many were willing to give the champion a mulligan.

But in the La Troienne at Churchill on April 30, Rachel Alexandra finished second by a head after a prolonged stretch battle with Unrivaled Belle.

Majority owner Jess Jackson nominated Rachel Alexandra to four stakes races this weekend and finally selected the Fleur de Lis earlier in the week. The race drew just four other entrants, all of whom Rachel Alexandra, the highweight at 124 pounds, towers over on paper. The filly breaks from post 4 under regular rider Calvin Borel and, barring poor racing luck, appears to have no excuses.

Made for Magic, who got in with 117 pounds, has two wins in seven starts this year, including the Grade II Milady Handicap in her most recent outing. The 5-year-old mare breaks from post 2 under Omar Berrio.

Trainer Marty Wolfson ships in Jessica Is Back, who hasn’t been off the board in three stakes starts this year. She won the listed Ocala Stakes two back and finished second in the Grade III Sixty Sails Handicap last time out. Garrett Gomez is in the irons and they leave from post 5.

Multipass (Jose Lezcano, rail) and Distinctive Dixie (Robby Albarado, post 3) are seeking their first stakes wins. Multipass finished third in an allowance/optional claimer last out and hasn’t been on the board against graded company. Distinctive Dixie, coming off a fourth-place finish in the La Troienne, is 2-for-4 at Churchill.

Rachel Alexandra is the star attraction on the undercard of the Grade I Stephen Foster Handicap, a $600,000-added event that has drawn some of the best older males in training. The morning-line favorite is the regally-bred Battle Plan, who has won four straight for Todd Pletcher since returning from an injury. Most recently, he earned a frontrunning victory in the Grade II New Orleans Handicap in March.

The son of Belmont winner Empire Maker, out of champion filly and Grade I producer Flanders, drew post 2 for the nine furlong race. Javier Castellano is in the irons.

The co-highweights at 120 pounds — a pound more than Battle Plan — are Blame, Arson Squad, and General Quarters. Blame (Gomez, post 11), winner of the Clark last fall at Churchill Downs, comes in off a victory in his 2010 debut, the William Donald Schaefer at Pimlico on Preakness weekend. The millionaire and multiple graded winner Arson Squad (Paco Lopez, post 5) hasn’t been unplaced in four starts this year, with a win in the Alysheba at Churchill last time out. General Quarters (Alex Solis, post 6) is looking for a Grade I win on dirt to go with his scores on synthetic in the 2009 Blue Grass and turf last time out in the Woodford Reserve.

Also in the field is defending champion Macho Again, a multiple graded winner who breaks from the nine under regular rider Albarado.

A.U. Miner (Francisco Torres, rail), Giant Oak (Shaun Bridgmohan, post 3), Duke of Mischief (Eibar Coa, post 4), Honest Man (Lezcano, post 7), No Advantage (Borel, post 8) and Demarcation (Miguel Mena, post 10) complete the field.

In addition to the Fleur de Lis and the Foster, Churchill Downs will card three other graded stakes this afternoon: The Grade III Jefferson Cup for 3-year-olds on the turf; the Grade III Regret for 3-year-old fillies on the turf; and the Grade III Northern Dancer for 3-year-olds on the main track.